US Patent #7999107

Publication number US7999107 B2 Publication type Grant

Application number US 12/009,114 Publication date 16 Aug 2011

Priority date 31 Jan 2007 Fee status Lapsed

Also published as CA2676167A1, CA2676167A1, DE602008005405D1, EP2109615A1, EP2109615B1, US20080207666, WO2008094476A1

Inventors John S. Debenham, 5 More

Original Assignee Merck Sharp & Dohme Corp.

Export Citation BiBTeX, EndNote, RefMan

Patent Citations (26), Non-Patent Citations (19), Referenced by (1), Classifications (10), Legal Events (5)

External Links: USPTO, USPTO Assignment, Espacenet (European P.O.)

Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators

US 7999107 B2

Abstract

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer’s disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson’s disease, Huntington’s disease movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.

BACKGROUND OF THE INVENTION

Marijuana (Cannabis sativa L.) and its derivatives have been used for centuries for medicinal and recreational purposes. ………….